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Peptide-based Inhibitors of Plk1 Polo-box Domain Containing Mono-anionic Phosphothreonine Esters and Their Pivaloyloxymethyl Prodrugs
Binding of polo-like kinase 1 (Plk1) polo-box domains (PBDs) to phosphothreonine (pThr)/phosphoserine (pSer)-containing sequences is critical for the proper function of Plk1. Although high affinity synthetic pThr-containing peptides may be used to disrupt PBD function, the efficacy of such peptides...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859306/ https://ncbi.nlm.nih.gov/pubmed/24120332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.09.005 |
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