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Peptide-based Inhibitors of Plk1 Polo-box Domain Containing Mono-anionic Phosphothreonine Esters and Their Pivaloyloxymethyl Prodrugs

Binding of polo-like kinase 1 (Plk1) polo-box domains (PBDs) to phosphothreonine (pThr)/phosphoserine (pSer)-containing sequences is critical for the proper function of Plk1. Although high affinity synthetic pThr-containing peptides may be used to disrupt PBD function, the efficacy of such peptides...

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Dettagli Bibliografici
Autori principali: Qian, Wen-Jian, Park, Jung-Eun, Lim, Dan, Park, Suk-Youl, Lee, Ki -Won, Yaffe, Michael B., Lee, Kyung S., Burke, Terrence R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859306/
https://ncbi.nlm.nih.gov/pubmed/24120332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2013.09.005
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