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Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk

Members of the polo subfamily of protein kinases play pivotal roles in cell proliferation. In addition to the kinase domain, polo kinases have a strikingly conserved sequence in the noncatalytic domain, termed the polo-box. The function of the polo-box is currently undefined. The mammalian polo-like...

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Detalhes bibliográficos
Main Authors: Lee, Kyung S., Grenfell, Tallessyn Z., Yarm, Frederic R., Erikson, Raymond L.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21333/
https://ncbi.nlm.nih.gov/pubmed/9689075
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