Mutation of the polo-box disrupts localization and mitotic functions of the mammalian polo kinase Plk

Members of the polo subfamily of protein kinases play pivotal roles in cell proliferation. In addition to the kinase domain, polo kinases have a strikingly conserved sequence in the noncatalytic domain, termed the polo-box. The function of the polo-box is currently undefined. The mammalian polo-like...

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Bibliographic Details
Main Authors: Lee, Kyung S., Grenfell, Tallessyn Z., Yarm, Frederic R., Erikson, Raymond L.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 1998
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC21333/
https://ncbi.nlm.nih.gov/pubmed/9689075
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