Mono-anionic Phosphopeptides Produced by Unexpected Histidine Alkylation Exhibit High Plk1 Polo-box Domain-binding Affinities and Enhanced Antiproliferative Effects in HeLa Cells

Binding of polo-like kinase 1 (Plk1) polo-box domains (PBDs) to phosphothreonine (pThr)/phosphoserine (pSer)-containing sequences is critical for the proper function of Plk1. Although high-affinity synthetic pThr-containing peptides provide starting points for developing PBD-directed inhibitors, to...

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Publicado no:Biopolymers
Main Authors: Qian, Wen-Jian, Park, Jung-Eun, Lim, Dan, Lai, Christopher C., Kelley, James A., Park, Suk-Youl, Lee, Ki-Won, Yaffe, Michael B., Lee, Kyung S., Burke, Terrence R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4895914/
https://ncbi.nlm.nih.gov/pubmed/25283071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bip.22569
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