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Phosphatase-stable Phosphoamino Acid Mimetics that Enhance Binding Affinities with the Polo-Box Domain of Polo-like Kinase 1
(2S,3R)-2-Amino-3-methyl-4-phosphono-butanoic acid (Pmab) is a phosphatase-stable analog of phosphothreonine (pThr), which has been used in a variety of biological contexts. Among these applications are peptidomimetic ligands that bind to the polo-box domain (PBD) of polo-like kinase 1 (Plk1) with a...
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| Publicado no: | ChemMedChem |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5340193/ https://ncbi.nlm.nih.gov/pubmed/27992122 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600574 |
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