Cyclic Peptides Containing Tryptophan and Arginine as Src Kinase Inhibitors

Por Shirazi, Amir Nasrolahi, Tiwari, Rakesh Kumar, Brown, Alex, Mandal, Dindyal, Sun, Gongqin, Parang, Keykavous
Publicado em 2013

Ensemble-based virtual screening for cannabinoid-like potentiators of the human glycine receptor α1 for the treatment of pain

Por Wells, Marta M., Tillman, Tommy S., Mowrey, David D., Sun, Tianmo, Xu, Yan, Tang, Pei
Publicado no J Med Chem (2015)

New Insights into Structure–Activity Relationship of Ipomoeassin F from Its Bioisosteric 5-Oxa/Aza Analogues

Por Zong, Guanghui, Sun, Xianwei, Bhakta, Rima, Whisenhunt, Lucas, Hu, Zhijian, Wang, Feng, Shi, Wei Q.
Publicado no Eur J Med Chem (2017)

Synthesis and SAR study of 4-hydroxy-3-(2-hydroxynapthalene-1-yl)phenyl)-arylsulfonamides: Heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay

Por Ganesh, Thota, Thepchatri, Pahk, Li, Lian, Du, Yuhong, Fu, Haian, Snyder, James P., Sun, Aiming
Publicado em 2008

Development of potent μ and δ opioid agonists with high lipophilicity

Por Lee, Yeon Sun, Kulkarani, Vinod, Cowell, Scott M., Ma, Shou-wu, Davis, Peg, Hanlon, Katherine E., Vanderah, Todd W., Lai, Josephine, Porreca, Frank, Vardanyan, Ruben, Hruby, Victor J.
Publicado em 2010

Structure-activity Relationship Studies of QS11, a Small Molecule Wnt Synergistic Agonist

Por Singh, Manish K., Gao, Huanyao, Sun, Wei, Song, Zhiquan, Schmalzigaug, Robert, Premontand, Richard T., Zhang, Qisheng
Publicado no Bioorg Med Chem Lett (2015)

Efficient synthesis and biological evaluation of epiceanothic acid and related compounds

Por Zhang, Pu, Xu, Li, Qian, Keduo, Liu, Jun, Zhang, Luyong, Lee, Kuo-Hsiung, Sun, Hongbin
Publicado em 2010

Discovery, Synthesis, and Biological Evaluation of Piperidinol analogs With Anti-tuberculosis Activity

Por Sun, Dianqing, Scherman, Michael S., Jones, Victoria, Hurdle, Julian G., Woolhiser, Lisa K., Knudson, Susan E., Lenaerts, Anne J., Slayden, Richard A., McNeil, Michael R., Lee, Richard E.
Publicado em 2009

Synthesis and Structure–Activity Relationship Studies of N-Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity again...

Por Dexheimer, Thomas S., Rosenthal, Andrew S., Luci, Diane K., Liang, Qin, Villamil, Mark A., Chen, Junjun, Sun, Hongmao, Kerns, Edward H., Simeonov, Anton, Jadhav, Ajit, Zhuang, Zhihao, Maloney, David J.
Publicado em 2014

Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase

Por Cox, Bryan D., Prosser, Anthony R., Sun, Yongnian, Li, Zhufang, Lee, Sangil, Huang, Ming B., Bond, Vincent C., Snyder, James P., Krystal, Mark, Wilson, Lawrence J., Liotta, Dennis C.
Publicado no ACS Med Chem Lett (2015)

Identification of triazinoindol-benzimidazolones as nanomolar inhibitors of the Mycobacterium tuberculosis enzyme TDP-6-deoxy-D-xylo-4-hexopyranosid-4-ulose 3,5-epimerase (RmlC)

Por Sivendran, Sharmila, Jones, Victoria, Sun, Dianqing, Wang, Yi, Grzegorzewicz, Anna E., Scherman, Michael S., Napper, Andrew D., McCammon, J. Andrew, Lee, Richard E., Diamond, Scott L., McNeil, Michael
Publicado em 2009

Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System

Por Wang, Xiaojing, Sun, Minghua, New, Connie, Nam, Spencer, Blackaby, Wesley P., Hodges, Alastair J., Nash, David, Matteucci, Mizio, Lyssikatos, Joseph P., Fan, Peter W., Tay, Suzanne, Chang, Jae H.
Publicado no ACS Med Chem Lett (2015)

An osteoclast-targeting agent for imaging and therapy of bone metastasis

Por Liu, Wei, Hajibeigi, Asghar, Lin, Mai, Rostollan, Cynthia L., Kovacs, Zoltan, Öz, Orhan K., Sun, Xiankai
Publicado em 2008

In vivo evaluation of medical device-associated inflammation using a macrophage-specific Positron Emission Tomography (PET) imaging probe

Por Zhou, Jun, Hao, Guiyang, Weng, Hong, Tsai, Yi-Ting, Baker, David W., Sun, Xiankai, Tang, Liping
Publicado em 2013

Synthesis and antibacterial evaluation of macrocyclic diarylheptanoid derivatives

Por Lin, Hao, Bruhn, David F., Maddox, Marcus M., Singh, Aman P., Lee, Richard E., Sun, Dianqing
Publicado no Bioorg Med Chem Lett (2016)

Enantiomer discrimination illustrated by high resolution crystal structures of type 4 phosphodiesterase

Por Huai, Qing, Sun, Yingjie, Wang, Huanchen, Macdonald, Dwight, Aspiotis, Renée, Robinson, Howard, Huang, Zheng, Ke, Hengming
Publicado em 2006

Far-red Light-activatable Prodrug of Paclitaxel for the Combined Effects of Photodynamic Therapy and Site-specific Paclitaxel Chemotherapy

Por Thapa, Pritam, Li, Mengjie, Bio, Moses, Rajaputra, Pallavi, Nkepang, Gregory, Sun, Yajing, Woo, Sukyung, You, Youngjae
Publicado no J Med Chem (2016)

Design, Synthesis, and Biological Evaluation of Resveratrol Analogues as Aromatase and Quinone Reductase 2 Inhibitors for Chemoprevention of Cancer

Por Sun, Bin, Hoshino, Juma, Jermihov, Katie, Marler, Laura, Pezzuto, John M., Mesecar, Andrew D., Cushman, Mark
Publicado em 2010

Novel hexadentate and pentadentate chelators for (64)Cu-based targeted PET imaging

Por Sin, Inseok, Kang, Chisoo, Bandara, Nilantha, Sun, Xiang, Zhong, Yongliang, Rogers, Buck E., Chong, Hyun-Soon
Publicado em 2014

Novel synthetic chalcones induce apoptosis in the A549 non-small cell lung cancer cells harboring a KRAS mutation

Por Wang, Yiqiang, Hedblom, Andreas, Koerner, Steffi K., Li, Mailin, Jernigan, Finith E., Wegiel, Barbara, Sun, Lijun
Publicado no Bioorg Med Chem Lett (2016)