Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System

[Image: see text] Time-dependent inhibition (TDI) of cytochrome P450 (CYP) enzymes may incur serious undesirable drug–drug interactions and in rare cases drug-induced idiosyncratic toxicity. The reactive metabolites are often generated through multiple sequential biotransformations and form adducts...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Wang, Xiaojing, Sun, Minghua, New, Connie, Nam, Spencer, Blackaby, Wesley P., Hodges, Alastair J., Nash, David, Matteucci, Mizio, Lyssikatos, Joseph P., Fan, Peter W., Tay, Suzanne, Chang, Jae H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2015
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4538442/
https://ncbi.nlm.nih.gov/pubmed/26288695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00191
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