Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase

[Image: see text] We report novel anti-HIV-1 agents with combined dual host–pathogen pharmacology. Lead compound 3, composed of a pyrazole-piperidine core, exhibits three concurrent mechanisms of action: (1) non-nucleoside reverse transcriptase inhibition, (2) CCR5-mediated M-tropic viral entry inhi...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:ACS Med Chem Lett
Hlavní autoři: Cox, Bryan D., Prosser, Anthony R., Sun, Yongnian, Li, Zhufang, Lee, Sangil, Huang, Ming B., Bond, Vincent C., Snyder, James P., Krystal, Mark, Wilson, Lawrence J., Liotta, Dennis C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2015
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499816/
https://ncbi.nlm.nih.gov/pubmed/26191361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00036
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky