A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

BACKGROUND: Heart rate follows a diurnal variation, and slow heart rhythms occur primarily at night. OBJECTIVE: The lower heart rate during sleep is assumed to be neural in origin, but here we tested whether a day-night difference in intrinsic pacemaking is involved. METHODS: In vivo and in vitro el...

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Dettagli Bibliografici
Pubblicato in:Heart Rhythm
Autori principali: D’Souza, Alicia, Wang, Yanwen, Anderson, Cali, Bucchi, Annalisa, Baruscotti, Mirko, Olieslagers, Servé, Mesirca, Pietro, Johnsen, Anne Berit, Mastitskaya, Svetlana, Ni, Haibo, Zhang, Yu, Black, Nicholas, Cox, Charlotte, Wegner, Sven, Bano-Otalora, Beatriz, Petit, Cheryl, Gill, Eleanor, Logantha, Sunil Jit R.J., Dobrzynski, Halina, Ashton, Nick, Hart, George, Zhang, Rai, Zhang, Henggui, Cartwright, Elizabeth J., Wisloff, Ulrik, Mangoni, Matteo E., da Costa Martins, Paula A., Piggins, Hugh D., DiFrancesco, Dario, Boyett, Mark R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2021
Soggetti:
Experimental
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8073545/
https://ncbi.nlm.nih.gov/pubmed/33278629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2020.11.026
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