Integrated Allosteric Model of Voltage Gating of Hcn Channels

Hyperpolarization-activated (pacemaker) channels are dually gated by negative voltage and intracellular cAMP. Kinetics of native cardiac f-channels are not compatible with HH gating, and require closed/open multistate models. We verified that members of the HCN channel family (mHCN1, hHCN2, hHCN4) a...

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Autors principals: Altomare, Claudia, Bucchi, Annalisa, Camatini, Eva, Baruscotti, Mirko, Viscomi, Carlo, Moroni, Anna, DiFrancesco, Dario
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2001
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2232403/
https://ncbi.nlm.nih.gov/pubmed/11382803
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