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Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models

In the adult animal the sinoatrial node (SAN) rhythmically generates a depolarizing wave that propagates to the rest of the heart. However, the SAN is more than a simple clock; it is a clock that adjusts its pace according to the metabolic requirements of the organism. The Hyperpolarization-activate...

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Библиографические подробности
Главные авторы: Bucchi, Annalisa, Barbuti, Andrea, DiFrancesco, Dario, Baruscotti, Mirko
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Research Foundation 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387723/
https://ncbi.nlm.nih.gov/pubmed/22783204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2012.00240
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