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Identification of the Molecular Site of Ivabradine Binding to HCN4 Channels
Ivabradine is a specific heart rate-reducing agent approved as a treatment of chronic stable angina. Its mode of action involves a selective and specific block of HCN channels, the molecular components of sinoatrial "funny" (f)-channels. Different studies suggest that the binding site of i...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3537762/ https://ncbi.nlm.nih.gov/pubmed/23308150 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053132 |
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