Identification of the Molecular Site of Ivabradine Binding to HCN4 Channels

Ivabradine is a specific heart rate-reducing agent approved as a treatment of chronic stable angina. Its mode of action involves a selective and specific block of HCN channels, the molecular components of sinoatrial "funny" (f)-channels. Different studies suggest that the binding site of i...

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Detaylı Bibliyografya
Asıl Yazarlar: Bucchi, Annalisa, Baruscotti, Mirko, Nardini, Marco, Barbuti, Andrea, Micheloni, Stefano, Bolognesi, Martino, DiFrancesco, Dario
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2013
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537762/
https://ncbi.nlm.nih.gov/pubmed/23308150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053132
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