Exercise training reduces resting heart rate via downregulation of the funny channel HCN4

Endurance athletes exhibit sinus bradycardia, that is a slow resting heart rate, associated with a higher incidence of sinus node (pacemaker) disease and electronic pacemaker implantation. Here we show that training-induced bradycardia is not a consequence of changes in the activity of the autonomic...

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Main Authors: D’Souza, Alicia, Bucchi, Annalisa, Johnsen, Anne Berit, Logantha, Sunil Jit R.J., Monfredi, Oliver, Yanni, Joseph, Prehar, Sukhpal, Hart, George, Cartwright, Elizabeth, Wisloff, Ulrik, Dobryznski, Halina, DiFrancesco, Dario, Morris, Gwilym M., Boyett, Mark R.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4024745/
https://ncbi.nlm.nih.gov/pubmed/24825544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4775
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