Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia

RATIONALE: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, I(f), underlies exercise training–induced sinus bradycardia in rodents. If this occurs in humans, it could explain the increased inciden...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: D’Souza, Alicia, Pearman, Charles M., Wang, Yanwen, Nakao, Shu, Logantha, Sunil Jit R.J., Cox, Charlotte, Bennett, Hayley, Zhang, Yu, Johnsen, Anne Berit, Linscheid, Nora, Poulsen, Pi Camilla, Elliott, Jonathan, Coulson, Jessica, McPhee, Jamie, Robertson, Abigail, da Costa Martins, Paula A., Kitmitto, Ashraf, Wisløff, Ulrik, Cartwright, Elizabeth J., Monfredi, Oliver, Lundby, Alicia, Dobrzynski, Halina, Oceandy, Delvac, Morris, Gwilym M., Boyett, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2017
Assuntos:
Molecular Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636198/
https://ncbi.nlm.nih.gov/pubmed/28821541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311607
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