Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia

RATIONALE: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, I(f), underlies exercise training–induced sinus bradycardia in rodents. If this occurs in humans, it could explain the increased inciden...

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Bibliografske podrobnosti
izdano v:Circ Res
Main Authors: D’Souza, Alicia, Pearman, Charles M., Wang, Yanwen, Nakao, Shu, Logantha, Sunil Jit R.J., Cox, Charlotte, Bennett, Hayley, Zhang, Yu, Johnsen, Anne Berit, Linscheid, Nora, Poulsen, Pi Camilla, Elliott, Jonathan, Coulson, Jessica, McPhee, Jamie, Robertson, Abigail, da Costa Martins, Paula A., Kitmitto, Ashraf, Wisløff, Ulrik, Cartwright, Elizabeth J., Monfredi, Oliver, Lundby, Alicia, Dobrzynski, Halina, Oceandy, Delvac, Morris, Gwilym M., Boyett, Mark R.
Format: Artigo
Jezik:Inglês
Izdano: Lippincott Williams & Wilkins 2017
Teme:
Molecular Medicine
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636198/
https://ncbi.nlm.nih.gov/pubmed/28821541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311607
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