Targeting miR-423-5p Reverses Exercise Training–Induced HCN4 Channel Remodeling and Sinus Bradycardia

RATIONALE: Downregulation of the pacemaking ion channel, HCN4 (hyperpolarization-activated cyclic nucleotide gated channel 4), and the corresponding ionic current, I(f), underlies exercise training–induced sinus bradycardia in rodents. If this occurs in humans, it could explain the increased inciden...

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Détails bibliographiques
Publié dans:Circ Res
Auteurs principaux: D’Souza, Alicia, Pearman, Charles M., Wang, Yanwen, Nakao, Shu, Logantha, Sunil Jit R.J., Cox, Charlotte, Bennett, Hayley, Zhang, Yu, Johnsen, Anne Berit, Linscheid, Nora, Poulsen, Pi Camilla, Elliott, Jonathan, Coulson, Jessica, McPhee, Jamie, Robertson, Abigail, da Costa Martins, Paula A., Kitmitto, Ashraf, Wisløff, Ulrik, Cartwright, Elizabeth J., Monfredi, Oliver, Lundby, Alicia, Dobrzynski, Halina, Oceandy, Delvac, Morris, Gwilym M., Boyett, Mark R.
Format: Artigo
Langue:Inglês
Publié: Lippincott Williams & Wilkins 2017
Sujets:
Molecular Medicine
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5636198/
https://ncbi.nlm.nih.gov/pubmed/28821541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.117.311607
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