A circadian clock in the sinus node mediates day-night rhythms in Hcn4 and heart rate

BACKGROUND: Heart rate follows a diurnal variation, and slow heart rhythms occur primarily at night. OBJECTIVE: The lower heart rate during sleep is assumed to be neural in origin, but here we tested whether a day-night difference in intrinsic pacemaking is involved. METHODS: In vivo and in vitro el...

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Detalhes bibliográficos
Publicado no:Heart Rhythm
Main Authors: D’Souza, Alicia, Wang, Yanwen, Anderson, Cali, Bucchi, Annalisa, Baruscotti, Mirko, Olieslagers, Servé, Mesirca, Pietro, Johnsen, Anne Berit, Mastitskaya, Svetlana, Ni, Haibo, Zhang, Yu, Black, Nicholas, Cox, Charlotte, Wegner, Sven, Bano-Otalora, Beatriz, Petit, Cheryl, Gill, Eleanor, Logantha, Sunil Jit R.J., Dobrzynski, Halina, Ashton, Nick, Hart, George, Zhang, Rai, Zhang, Henggui, Cartwright, Elizabeth J., Wisloff, Ulrik, Mangoni, Matteo E., da Costa Martins, Paula A., Piggins, Hugh D., DiFrancesco, Dario, Boyett, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Experimental
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8073545/
https://ncbi.nlm.nih.gov/pubmed/33278629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.hrthm.2020.11.026
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