Genome-Scale Model-Based Identification of Metabolite Indicators for Early Detection of Kidney Toxicity

Identifying early indicators of toxicant-induced organ damage is critical to provide effective treatment. To discover such indicators and the underlying mechanisms of toxicity, we used gentamicin as an exemplar kidney toxicant and performed systematic perturbation studies in Sprague Dawley rats. We...

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Gepubliceerd in:Toxicol Sci
Hoofdauteurs: Pannala, Venkat R, Vinnakota, Kalyan C, Estes, Shanea K, Trenary, Irina, OˈBrien, Tracy P, Printz, Richard L, Papin, Jason A, Reifman, Jaques, Oyama, Tatsuya, Shiota, Masakazu, Young, Jamey D, Wallqvist, Anders
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Computational Toxicology and Databases
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000070/
https://ncbi.nlm.nih.gov/pubmed/31722432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz228
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