Genome-Scale Model-Based Identification of Metabolite Indicators for Early Detection of Kidney Toxicity

Identifying early indicators of toxicant-induced organ damage is critical to provide effective treatment. To discover such indicators and the underlying mechanisms of toxicity, we used gentamicin as an exemplar kidney toxicant and performed systematic perturbation studies in Sprague Dawley rats. We...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Pannala, Venkat R, Vinnakota, Kalyan C, Estes, Shanea K, Trenary, Irina, OˈBrien, Tracy P, Printz, Richard L, Papin, Jason A, Reifman, Jaques, Oyama, Tatsuya, Shiota, Masakazu, Young, Jamey D, Wallqvist, Anders
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
Computational Toxicology and Databases
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000070/
https://ncbi.nlm.nih.gov/pubmed/31722432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz228
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