Genome-Scale Model-Based Identification of Metabolite Indicators for Early Detection of Kidney Toxicity

Identifying early indicators of toxicant-induced organ damage is critical to provide effective treatment. To discover such indicators and the underlying mechanisms of toxicity, we used gentamicin as an exemplar kidney toxicant and performed systematic perturbation studies in Sprague Dawley rats. We...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Toxicol Sci
Päätekijät: Pannala, Venkat R, Vinnakota, Kalyan C, Estes, Shanea K, Trenary, Irina, OˈBrien, Tracy P, Printz, Richard L, Papin, Jason A, Reifman, Jaques, Oyama, Tatsuya, Shiota, Masakazu, Young, Jamey D, Wallqvist, Anders
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2019
Aiheet:
Computational Toxicology and Databases
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000070/
https://ncbi.nlm.nih.gov/pubmed/31722432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz228
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