Genome-Scale Model-Based Identification of Metabolite Indicators for Early Detection of Kidney Toxicity

Identifying early indicators of toxicant-induced organ damage is critical to provide effective treatment. To discover such indicators and the underlying mechanisms of toxicity, we used gentamicin as an exemplar kidney toxicant and performed systematic perturbation studies in Sprague Dawley rats. We...

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Опубликовано в: :Toxicol Sci
Главные авторы: Pannala, Venkat R, Vinnakota, Kalyan C, Estes, Shanea K, Trenary, Irina, OˈBrien, Tracy P, Printz, Richard L, Papin, Jason A, Reifman, Jaques, Oyama, Tatsuya, Shiota, Masakazu, Young, Jamey D, Wallqvist, Anders
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2019
Предметы:
Computational Toxicology and Databases
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC8000070/
https://ncbi.nlm.nih.gov/pubmed/31722432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz228
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