Mechanistic identification of biofluid metabolite changes as markers of acetaminophen-induced liver toxicity in rats

Acetaminophen (APAP) is the most commonly used analgesic and antipyretic drug in the world. Yet, it poses a major risk of liver injury when taken in excess of the therapeutic dose. Current clinical markers do not detect the early onset of liver injury associated with excess APAP—information that is...

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Veröffentlicht in:Toxicol Appl Pharmacol
Hauptverfasser: Pannala, Venkat R., Vinnakota, Kalyan C., Rawls, Kristopher D., Estes, Shanea K., O’Brien, Tracy P., Printz, Richard L., Papin, Jason A., Reifman, Jaques, Shiota, Masakazu, Young, Jamey D., Wallqvist, Anders
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599641/
https://ncbi.nlm.nih.gov/pubmed/30974156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.04.001
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