Metabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat

In order to provide timely treatment for organ damage initiated by therapeutic drugs or exposure to environmental toxicants, we first need to identify markers that provide an early diagnosis of potential adverse effects before permanent damage occurs. Specifically, the liver, as a primary organ pron...

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Udgivet i:Sci Rep
Main Authors: Pannala, Venkat R., Wall, Martha L., Estes, Shanea K., Trenary, Irina, O’Brien, Tracy P., Printz, Richard L., Vinnakota, Kalyan C., Reifman, Jaques, Shiota, Masakazu, Young, Jamey D., Wallqvist, Anders
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6076258/
https://ncbi.nlm.nih.gov/pubmed/30076366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-30149-7
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