Mechanistic identification of biofluid metabolite changes as markers of acetaminophen-induced liver toxicity in rats

Acetaminophen (APAP) is the most commonly used analgesic and antipyretic drug in the world. Yet, it poses a major risk of liver injury when taken in excess of the therapeutic dose. Current clinical markers do not detect the early onset of liver injury associated with excess APAP—information that is...

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Publié dans:Toxicol Appl Pharmacol
Auteurs principaux: Pannala, Venkat R., Vinnakota, Kalyan C., Rawls, Kristopher D., Estes, Shanea K., O’Brien, Tracy P., Printz, Richard L., Papin, Jason A., Reifman, Jaques, Shiota, Masakazu, Young, Jamey D., Wallqvist, Anders
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599641/
https://ncbi.nlm.nih.gov/pubmed/30974156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.04.001
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