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Polygenic risk and pleiotropy in neurodegenerative diseases

In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS) analysis. PRS was designed to assess a...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Bellou, Eftychia, Stevenson-Hoare, Joshua, Escott-Price, Valentina
Format: Artigo
Sprog:Inglês
Udgivet: Academic Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378564/
https://ncbi.nlm.nih.gov/pubmed/32445791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104953
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