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Polygenic risk and pleiotropy in neurodegenerative diseases

In this paper we explore the phenomenon of pleiotropy in neurodegenerative diseases, focusing on Alzheimer's disease (AD). We summarize the various techniques developed to investigate pleiotropy among traits, elaborating in the polygenic risk scores (PRS) analysis. PRS was designed to assess a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurobiol Dis
Prif Awduron: Bellou, Eftychia, Stevenson-Hoare, Joshua, Escott-Price, Valentina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Academic Press 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378564/
https://ncbi.nlm.nih.gov/pubmed/32445791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.104953
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