Type I IFN Sensing by cDCs and CD4(+) T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8(+) T Cells

Adeno-associated virus (AAV) vectors are widely used in clinical gene therapy to correct genetic disease by in vivo gene transfer. Although the vectors are useful, in part because of their limited immunogenicity, immune responses directed at vector components have complicated applications in humans....

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Dettagli Bibliografici
Pubblicato in:Mol Ther
Autori principali: Shirley, Jamie L., Keeler, Geoffrey D., Sherman, Alexandra, Zolotukhin, Irene, Markusic, David M., Hoffman, Brad E., Morel, Laurence M., Wallet, Mark A., Terhorst, Cox, Herzog, Roland W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054715/
https://ncbi.nlm.nih.gov/pubmed/31780366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.011
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