Type I IFN Sensing by cDCs and CD4(+) T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8(+) T Cells

Adeno-associated virus (AAV) vectors are widely used in clinical gene therapy to correct genetic disease by in vivo gene transfer. Although the vectors are useful, in part because of their limited immunogenicity, immune responses directed at vector components have complicated applications in humans....

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Bibliografische gegevens
Gepubliceerd in:Mol Ther
Hoofdauteurs: Shirley, Jamie L., Keeler, Geoffrey D., Sherman, Alexandra, Zolotukhin, Irene, Markusic, David M., Hoffman, Brad E., Morel, Laurence M., Wallet, Mark A., Terhorst, Cox, Herzog, Roland W.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2020
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054715/
https://ncbi.nlm.nih.gov/pubmed/31780366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.011
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