Type I IFN Sensing by cDCs and CD4(+) T Cell Help Are Both Requisite for Cross-Priming of AAV Capsid-Specific CD8(+) T Cells

Adeno-associated virus (AAV) vectors are widely used in clinical gene therapy to correct genetic disease by in vivo gene transfer. Although the vectors are useful, in part because of their limited immunogenicity, immune responses directed at vector components have complicated applications in humans....

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Bibliografiske detaljer
Udgivet i:Mol Ther
Main Authors: Shirley, Jamie L., Keeler, Geoffrey D., Sherman, Alexandra, Zolotukhin, Irene, Markusic, David M., Hoffman, Brad E., Morel, Laurence M., Wallet, Mark A., Terhorst, Cox, Herzog, Roland W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Gene & Cell Therapy 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7054715/
https://ncbi.nlm.nih.gov/pubmed/31780366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.11.011
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