Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol–Lactones as Protein Kinase C Ligands

Protein kinase C (PKC) mediates a central cellular signal transduction pathway involved in disorders such as cancer and Alzheimer’s disease. PKC is regulated by binding of the second messenger sn-1,2-diacylglycerol (DAG) to its tandem C1 domains, designated C1a and C1b, leading both to PKC activatio...

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Detalhes bibliográficos
Publicado no:Bioconjug Chem
Main Authors: Ohashi, Nami, Kobayashi, Ryosuke, Nomura, Wataru, Kobayakawa, Takuya, Czikora, Agnes, Herold, Brienna K., Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957264/
https://ncbi.nlm.nih.gov/pubmed/28671468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00299
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