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Synthesis and Evaluation of Dimeric Derivatives of Diacylglycerol–Lactones as Protein Kinase C Ligands

Protein kinase C (PKC) mediates a central cellular signal transduction pathway involved in disorders such as cancer and Alzheimer’s disease. PKC is regulated by binding of the second messenger sn-1,2-diacylglycerol (DAG) to its tandem C1 domains, designated C1a and C1b, leading both to PKC activatio...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Bioconjug Chem
Hauptverfasser: Ohashi, Nami, Kobayashi, Ryosuke, Nomura, Wataru, Kobayakawa, Takuya, Czikora, Agnes, Herold, Brienna K., Lewin, Nancy E., Blumberg, Peter M., Tamamura, Hirokazu
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957264/
https://ncbi.nlm.nih.gov/pubmed/28671468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.7b00299
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