Structure–Activity Relationship for the Oxadiazole Class of Antibiotics

The structure–activity relationship (SAR) for the newly discovered oxadiazole class of antibiotics is described with evaluation of 120 derivatives of the lead structure. This class of antibiotics was discovered by in silico docking and scoring against the crystal structure of a penicillin-binding pr...

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Bibliografski detalji
Izdano u:J Med Chem
Glavni autori: Spink, Edward, Ding, Derong, Peng, Zhihong, Boudreau, Marc A., Leemans, Erika, Lastochkin, Elena, Song, Wei, Lichtenwalter, Katerina, O’Daniel, Peter I., Testero, Sebastian A., Pi, Hualiang, Schroeder, Valerie A., Wolter, William R., Antunes, Nuno T., Suckow, Mark A., Vakulenko, Sergei, Chang, Mayland, Mobashery, Shahriar
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863074/
https://ncbi.nlm.nih.gov/pubmed/25590813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501661f
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