Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

[Image: see text] Infections caused by hard-to-treat methicillin-resistant Staphylococcus aureus (MRSA) are a serious global public-health concern, as MRSA has become broadly resistant to many classes of antibiotics. We disclose herein the discovery of a new class of non-β-lactam antibiotics, the ox...

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Hlavní autoři: O’Daniel, Peter I., Peng, Zhihong, Pi, Hualiang, Testero, Sebastian A., Ding, Derong, Spink, Edward, Leemans, Erika, Boudreau, Marc A., Yamaguchi, Takao, Schroeder, Valerie A., Wolter, William R., Llarrull, Leticia I., Song, Wei, Lastochkin, Elena, Kumarasiri, Malika, Antunes, Nuno T., Espahbodi, Mana, Lichtenwalter, Katerina, Suckow, Mark A., Vakulenko, Sergei, Mobashery, Shahriar, Chang, Mayland
Médium: Artigo
Jazyk:Inglês
Vydáno: American Chemical Society 2014
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985699/
https://ncbi.nlm.nih.gov/pubmed/24517363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja500053x
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