Discovery of a New Class of Non-β-lactam Inhibitors of Penicillin-Binding Proteins with Gram-Positive Antibacterial Activity

[Image: see text] Infections caused by hard-to-treat methicillin-resistant Staphylococcus aureus (MRSA) are a serious global public-health concern, as MRSA has become broadly resistant to many classes of antibiotics. We disclose herein the discovery of a new class of non-β-lactam antibiotics, the ox...

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Main Authors: O’Daniel, Peter I., Peng, Zhihong, Pi, Hualiang, Testero, Sebastian A., Ding, Derong, Spink, Edward, Leemans, Erika, Boudreau, Marc A., Yamaguchi, Takao, Schroeder, Valerie A., Wolter, William R., Llarrull, Leticia I., Song, Wei, Lastochkin, Elena, Kumarasiri, Malika, Antunes, Nuno T., Espahbodi, Mana, Lichtenwalter, Katerina, Suckow, Mark A., Vakulenko, Sergei, Mobashery, Shahriar, Chang, Mayland
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3985699/
https://ncbi.nlm.nih.gov/pubmed/24517363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja500053x
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