Structure–Activity Relationship for the Oxadiazole Class of Antibiotics

The structure–activity relationship (SAR) for the newly discovered oxadiazole class of antibiotics is described with evaluation of 120 derivatives of the lead structure. This class of antibiotics was discovered by in silico docking and scoring against the crystal structure of a penicillin-binding pr...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Spink, Edward, Ding, Derong, Peng, Zhihong, Boudreau, Marc A., Leemans, Erika, Lastochkin, Elena, Song, Wei, Lichtenwalter, Katerina, O’Daniel, Peter I., Testero, Sebastian A., Pi, Hualiang, Schroeder, Valerie A., Wolter, William R., Antunes, Nuno T., Suckow, Mark A., Vakulenko, Sergei, Chang, Mayland, Mobashery, Shahriar
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863074/
https://ncbi.nlm.nih.gov/pubmed/25590813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501661f
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