Structure–Activity Relationship for the Oxadiazole Class of Antibacterials

[Image: see text] A structure–activity relationship (SAR) for the oxadiazole class of antibacterials was evaluated by syntheses of 72 analogs and determination of the minimal-inhibitory concentrations (MICs) against the ESKAPE panel of bacteria. Selected compounds were further evaluated for in vitro...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Boudreau, Marc A., Ding, Derong, Meisel, Jayda E., Janardhanan, Jeshina, Spink, Edward, Peng, Zhihong, Qian, Yuanyuan, Yamaguchi, Takao, Testero, Sebastian A., O’Daniel, Peter I., Leemans, Erika, Lastochkin, Elena, Song, Wei, Schroeder, Valerie A., Wolter, William R., Suckow, Mark A., Mobashery, Shahriar, Chang, Mayland
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2019
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073871/
https://ncbi.nlm.nih.gov/pubmed/32184964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00379
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