Structure–Activity Relationship for the Oxadiazole Class of Antibacterials

[Image: see text] A structure–activity relationship (SAR) for the oxadiazole class of antibacterials was evaluated by syntheses of 72 analogs and determination of the minimal-inhibitory concentrations (MICs) against the ESKAPE panel of bacteria. Selected compounds were further evaluated for in vitro...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Boudreau, Marc A., Ding, Derong, Meisel, Jayda E., Janardhanan, Jeshina, Spink, Edward, Peng, Zhihong, Qian, Yuanyuan, Yamaguchi, Takao, Testero, Sebastian A., O’Daniel, Peter I., Leemans, Erika, Lastochkin, Elena, Song, Wei, Schroeder, Valerie A., Wolter, William R., Suckow, Mark A., Mobashery, Shahriar, Chang, Mayland
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7073871/
https://ncbi.nlm.nih.gov/pubmed/32184964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00379
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