Exploration of the Structure-Activity Relationship of 1,2,4-Oxadiazole Antibiotics

We have recently disclosed the discovery of the class of 1,2,4-oxadiazole antibiotics, which emerged from in silico docking and scoring efforts. This class of antibacterials exhibits Gram-positive activity, particularly against Staphylococcus aureus. We define the structure-activity relationship (SA...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Ding, Derong, Boudreau, Marc A., Leemans, Erika, Spink, Edward, Yamaguchi, Takao, Testero, Sebastian A., O’Daniel, Peter I., Lastochkin, Elena, Chang, Mayland, Mobashery, Shahriar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607640/
https://ncbi.nlm.nih.gov/pubmed/26144346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.06.044
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