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Mutations in mmpL and in the Cell Wall Stress Stimulon Contribute to Resistance to Oxadiazole Antibiotics in Methicillin-Resistant Staphylococcus aureus

Staphylococcus aureus is a leading cause of hospital- and community-acquired infections, which exhibit broad resistance to various antibiotics. We recently disclosed the discovery of the oxadiazole class of antibiotics, which has in vitro and in vivo activities against methicillin-resistant S. aureu...

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Main Authors: Xiao, Qiaobin, Vakulenko, Sergei, Chang, Mayland, Mobashery, Shahriar
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187926/
https://ncbi.nlm.nih.gov/pubmed/25049248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03501-14
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