Structure–Activity Relationship for the Oxadiazole Class of Antibiotics

The structure–activity relationship (SAR) for the newly discovered oxadiazole class of antibiotics is described with evaluation of 120 derivatives of the lead structure. This class of antibiotics was discovered by in silico docking and scoring against the crystal structure of a penicillin-binding pr...

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Dades bibliogràfiques
Publicat a:J Med Chem
Autors principals: Spink, Edward, Ding, Derong, Peng, Zhihong, Boudreau, Marc A., Leemans, Erika, Lastochkin, Elena, Song, Wei, Lichtenwalter, Katerina, O’Daniel, Peter I., Testero, Sebastian A., Pi, Hualiang, Schroeder, Valerie A., Wolter, William R., Antunes, Nuno T., Suckow, Mark A., Vakulenko, Sergei, Chang, Mayland, Mobashery, Shahriar
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6863074/
https://ncbi.nlm.nih.gov/pubmed/25590813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501661f
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