Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation

[Image: see text] Discovery of new chemotherapeutic lead agents can be accelerated by optimizing chemotypes proven to be effective in other diseases to act against parasites. One such medicinal chemistry campaign has focused on optimizing the anilinoquinazoline drug lapatinib (1) and the alkynyl thi...

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書誌詳細
出版年:ACS Med Chem Lett
主要な著者: Woodring, Jennifer L., Behera, Ranjan, Sharma, Amrita, Wiedeman, Justin, Patel, Gautam, Singh, Baljinder, Guyett, Paul, Amata, Emanuele, Erath, Jessey, Roncal, Norma, Penn, Erica, Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Mensa-Wilmot, Kojo, Pollastri, Michael P.
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2018
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187419/
https://ncbi.nlm.nih.gov/pubmed/30344906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00245
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