EVALUATION OF AROMATIC 6-SUBSTITUTED THIENOPYRIMIDINES AS SCAFFOLDS AGAINST PARASITES THAT CAUSE TRYPANOSOMIASIS, LEISHMANIASIS, AND MALARIA

Target repurposing is a proven method for finding new lead compounds that target Trypanosoma brucei, the causative agent of human African trypanosomiasis. Due to the recent discovery of a lapatinib-derived analog 2 with excellent potency against T. brucei (EC(50) = 42 nM) and selectivity over human...

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Detalhes bibliográficos
Publicado no:Medchemcomm
Main Authors: Woodring, Jennifer L., Patel, Gautam, Erath, Jessey, Behera, Ranjan, Lee, Patricia J., Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Mensa-Wilmot, Kojo, Pollastri, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4324364/
https://ncbi.nlm.nih.gov/pubmed/25685309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00441H
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