Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation

[Image: see text] Discovery of new chemotherapeutic lead agents can be accelerated by optimizing chemotypes proven to be effective in other diseases to act against parasites. One such medicinal chemistry campaign has focused on optimizing the anilinoquinazoline drug lapatinib (1) and the alkynyl thi...

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Τόπος έκδοσης:ACS Med Chem Lett
Κύριοι συγγραφείς: Woodring, Jennifer L., Behera, Ranjan, Sharma, Amrita, Wiedeman, Justin, Patel, Gautam, Singh, Baljinder, Guyett, Paul, Amata, Emanuele, Erath, Jessey, Roncal, Norma, Penn, Erica, Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Mensa-Wilmot, Kojo, Pollastri, Michael P.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Chemical Society 2018
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187419/
https://ncbi.nlm.nih.gov/pubmed/30344906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00245
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