Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation

[Image: see text] Discovery of new chemotherapeutic lead agents can be accelerated by optimizing chemotypes proven to be effective in other diseases to act against parasites. One such medicinal chemistry campaign has focused on optimizing the anilinoquinazoline drug lapatinib (1) and the alkynyl thi...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Woodring, Jennifer L., Behera, Ranjan, Sharma, Amrita, Wiedeman, Justin, Patel, Gautam, Singh, Baljinder, Guyett, Paul, Amata, Emanuele, Erath, Jessey, Roncal, Norma, Penn, Erica, Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Mensa-Wilmot, Kojo, Pollastri, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2018
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187419/
https://ncbi.nlm.nih.gov/pubmed/30344906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00245
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