Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery

Hesperadin, an established human Aurora B inhibitor, was tested against cultures of Trypanosoma brucei, Leishmania major, and Plasmodium falciparum, and was identified to be a potent proliferation inhibitor. A series of analogs was designed and tested to establish the initial structure-activity rela...

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Hauptverfasser: Patel, Gautam, Roncal, Norma E., Lee, Patricia J., Leed, Susan E., Erath, Jessey, Rodriguez, Ana, Sciotti, Richard J., Pollastri, Michael P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4045489/
https://ncbi.nlm.nih.gov/pubmed/24910766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00045E
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