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Repurposing human Aurora kinase inhibitors as leads for anti-protozoan drug discovery
Hesperadin, an established human Aurora B inhibitor, was tested against cultures of Trypanosoma brucei, Leishmania major, and Plasmodium falciparum, and was identified to be a potent proliferation inhibitor. A series of analogs was designed and tested to establish the initial structure-activity rela...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4045489/ https://ncbi.nlm.nih.gov/pubmed/24910766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C4MD00045E |
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