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Identification of “Preferred” Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?

[Image: see text] A kinase-targeting cell-based high-throughput screen (HTS) against Trypanosoma brucei was recently reported, and this screening set included the Published Kinase Inhibitor Set (PKIS). From the PKIS was identified 53 compounds with pEC(50) ≥ 6. Utilizing the published data available...

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Detalhes bibliográficos
Publicado no:ACS Infect Dis
Main Authors: Amata, Emanuele, Xi, Hualin, Colmenarejo, Gonzalo, Gonzalez-Diaz, Rosario, Cordon-Obras, Carlos, Berlanga, Manuela, Manzano, Pilar, Erath, Jessey, Roncal, Norma E., Lee, Patricia J., Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Navarro, Miguel, Pollastri, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2016
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4791575/
https://ncbi.nlm.nih.gov/pubmed/26998514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00136
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