Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation

[Image: see text] Discovery of new chemotherapeutic lead agents can be accelerated by optimizing chemotypes proven to be effective in other diseases to act against parasites. One such medicinal chemistry campaign has focused on optimizing the anilinoquinazoline drug lapatinib (1) and the alkynyl thi...

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Bibliografiset tiedot
Julkaisussa:ACS Med Chem Lett
Päätekijät: Woodring, Jennifer L., Behera, Ranjan, Sharma, Amrita, Wiedeman, Justin, Patel, Gautam, Singh, Baljinder, Guyett, Paul, Amata, Emanuele, Erath, Jessey, Roncal, Norma, Penn, Erica, Leed, Susan E., Rodriguez, Ana, Sciotti, Richard J., Mensa-Wilmot, Kojo, Pollastri, Michael P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2018
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6187419/
https://ncbi.nlm.nih.gov/pubmed/30344906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00245
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