Inhibition of Dpp8/9 Activates the Nlrp1b Inflammasome

Val-boroPro (PT-100, Talabostat) induces powerful anti-tumor immune responses in syngeneic cancer models, but its mechanism of action has not yet been established. Val-boroPro is a non-selective inhibitor of post-proline-cleaving serine proteases, and the inhibition of the highly related cytosolic s...

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Bibliographic Details
Published in:Cell Chem Biol
Main Authors: Okondo, Marian C., Rao, Sahana D., Taabazuing, Cornelius Y., Chui, Ashley J., Poplawski, Sarah E., Johnson, Darren C., Bachovchin, Daniel A.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5856610/
https://ncbi.nlm.nih.gov/pubmed/29396289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.12.013
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