Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer’s Disease

Eitemau Tebyg

• A Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms
  gan: Derrick, Jeffrey S., et al.
  Cyhoeddwyd: (2015)
• Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation
  gan: Korshavn, Kyle, et al.
  Cyhoeddwyd: (2016)
• Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer’s disease
  gan: Beck, Michael W., et al.
  Cyhoeddwyd: (2017)
• A Small Molecule that Displays Marked Reactivity with Copper– versus Zinc–Amyloid-β Implicated in Alzheimer’s Disease
  gan: Savelieff, Masha G., et al.
  Cyhoeddwyd: (2013)
• An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation
  gan: Kang, Juhye, et al.
  Cyhoeddwyd: (2017)