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Amyloid-β adopts a conserved, partially folded structure upon binding to zwitterionic lipid bilayers prior to amyloid formation
Aggregation at the neuronal cell membrane’s lipid bilayer surface is implicated in amyloid-β (Aβ) toxicity associated with Alzheimer’s disease; however, structural and mechanistic insights into the process remain scarce. We have identified a conserved binding mode of Aβ(40) on lipid bilayer surfaces...
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| Publicado en: | Chem Commun (Camb) |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4703560/ https://ncbi.nlm.nih.gov/pubmed/26553596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5cc08634e |
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