Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives

Both amyloid-β (Aβ) and transition metal ions are shown to be involved in the pathogenesis of Alzheimer’s disease (AD), though the importance of their interactions remains unclear. Multifunctional molecules, which can target metal-free and metal-bound Aβ and modulate their reactivity (e.g., Aβ aggre...

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Publicado no:Sci Rep
Main Authors: Korshavn, Kyle J., Jang, Milim, Kwak, Yeon Ju, Kochi, Akiko, Vertuani, Silvia, Bhunia, Anirban, Manfredini, Stefano, Ramamoorthy, Ayyalusamy, Lim, Mi Hee
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4674742/
https://ncbi.nlm.nih.gov/pubmed/26657338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep17842
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