Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

The aggregation of amyloid-β (Aβ) on lipid bilayers has been implicated as a mechanism by which Aβ exerts its toxicity in Alzheimer's disease (AD). Lipid bilayer thinning has been observed during both oxidative stress and protein aggregation in AD, but whether these pathological modifications o...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Korshavn, Kyle J., Satriano, Cristina, Lin, Yuxi, Zhang, Rongchun, Dulchavsky, Mark, Bhunia, Anirban, Ivanova, Magdalena I., Lee, Young-Ho, La Rosa, Carmelo, Lim, Mi Hee, Ramamoorthy, Ayyalusamy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377779/
https://ncbi.nlm.nih.gov/pubmed/28154182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764092
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