Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β

The aggregation of amyloid-β (Aβ) on lipid bilayers has been implicated as a mechanism by which Aβ exerts its toxicity in Alzheimer's disease (AD). Lipid bilayer thinning has been observed during both oxidative stress and protein aggregation in AD, but whether these pathological modifications o...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Korshavn, Kyle J., Satriano, Cristina, Lin, Yuxi, Zhang, Rongchun, Dulchavsky, Mark, Bhunia, Anirban, Ivanova, Magdalena I., Lee, Young-Ho, La Rosa, Carmelo, Lim, Mi Hee, Ramamoorthy, Ayyalusamy
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5377779/
https://ncbi.nlm.nih.gov/pubmed/28154182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.764092
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